The long-term vision of the future Aguado iBiomaterials Research Group will be to develop personalized biomaterials that enable the evaluation of a patient’s unique biology to diagnose and treat a variety of health disorders.
IMPLANTABLE MATERIALS FOR EARLY METASTASIS DETECTION
The spread of tumor cells to target organs (i.e. metastasis) indicates the stage at which cancer is deemed incurable. We have developed implantable materials that recruit tumor cells away from target organs to the implant site. Our materials may enable early detection and treatment of metastasis.
PATIENT-SPECIFIC MODELS OF AORTIC VALVE DISEASE
Small molecule inhibitors of aortic valve disease remain elusive. We have engineered in vitro models of valve disease using human serum from patients with valve disease and hydrogels to culture valvular cells. Our models may allow for personalized drug discovery for patients with valve disease.
BIOMATERIALS TO STUDY SEX-SPECIFIC CARDIAC DISEASES
Cardiovascular disorders are the leading cause of death in both men and women. However, the molecular and cellular mechanisms guiding cardiovascular disease progression in women remain poorly characterized. We seek to use precision biomaterials as tools to determine sex-specific mechanisms of cardiovascular disease progression.